Adult Zebrafish Model of Streptococcal Infection

Adult zebrafish model of streptococcal infection.

Streptococcal pathogens cause a wide array of clinical syndromes in humans, including invasive systemic infections resulting in high mortality rates. Many of these pathogens are human specific, and therefore difficult to analyze in vivo using typical animal models, as these models rarely replicate what is observed in human infections. This unit describes the use of the zebrafish (Danio rerio) a...

Extreme eosinophilia due to common streptococcal infection in an adult.

Perianal streptococcal infection precipitating pustular psoriasis in an adult

Fig 1. Well-demarcated salmon-pink to erythematous plaque with overlying scale and pustules on the right side of the groin. CASE REPORT A68-year-oldmanwhowasotherwisewell,with no personal or family history of skin disease and not on any regular medications, developed a perianal/groin irritation after a digital prostate examination. His general practitioner diagnosed seborrheic dermatitis with s...

Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection.

Streptococcal pyrogenic exotoxin B (SPE B) is a cysteine protease produced by Streptococcus pyogenes. In this study, the differences in virulence between protease-positive clinical isolates and their protease-negative mutants were examined in a mouse model. Isogenic protease-negative mutants were constructed by homologous recombination, using integrational plasmids to disrupt the speB gene. The...

Immunisation of Adult Sheep Against Brucella Infection